Title

Alkyl Ether Derivatives of the FK-506 Related, Immunosuppressive Macrolide L-683,742 (C31-O-Desmethyl Ascomycin)

Document Type

Article

Publication Date

1-1-1994

Abstract

Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.

DOI

10.1016/S0960-894X(01)80265-1

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