Alkyl Ether Derivatives of the FK-506 Related, Immunosuppressive Macrolide L-683,742 (C31-O-Desmethyl Ascomycin)
Ether derivatives of the FK-506 related macrolide L-683,742 (C31-O-desmethyl ascomycin) have been prepared by alkylation with various alkyl 2,2,2-trichloroacetimidates. The in vitro immunosuppressive activity of these analogs is dependent both on the size and site of attachment (C31-O vs. C32-O) of the ether group.
MSU Digital Commons Citation
Goulet, Mark T.; Hodkey, Derek W.; Staruch, Mary Jo; Dumont, Francis J.; Lin, C. Shirley; Hung, Shirley H Y; Siekierka, John; and Wyvratt, Matthew J., "Alkyl Ether Derivatives of the FK-506 Related, Immunosuppressive Macrolide L-683,742 (C31-O-Desmethyl Ascomycin)" (1994). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 123.