Document Type
Article
Publication Date
7-1-2023
Journal / Book Title
Medicinal Chemistry Research
Abstract
Drug discovery is a difficult task, and is even more challenging when the target evolves during therapy. Antiviral drug therapy is an excellent example, exemplified by the evolution of therapeutic approaches for treatment of hepatitis C and HIV-1. Nick Meanwell and his colleagues made important contributions leading to molecules for treatment of hepatitis C and HIV-1, each with distinct mechanisms of action. This review summarizes the discovery and impact of these drugs, and will highlight, where applicable, the broader contributions of these discoveries to medicinal chemistry and drug discovery.
DOI
10.1007/s00044-023-03086-y
Montclair State University Digital Commons Citation
Rotella, David P., "Successes in antiviral drug discovery: a tribute to Nick Meanwell" (2023). Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works. 649.
https://digitalcommons.montclair.edu/chem-biochem-facpubs/649
Rights
This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
Published Citation
Rotella D. P. (2023). Successes in antiviral drug discovery: a tribute to Nick Meanwell. Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 1–10. Advance online publication. https://doi.org/10.1007/s00044-023-03086-y