Journal / Book Title
Cancer Causes Control
Worldwide, there are more than 10 million new cancer cases each year, and cancer is the cause of approximately 12% of all deaths. Given this, a large number of epidemiologic studies have been undertaken to identify potential risk factors for cancer, amongst which the association with trace elements has received considerable attention. Trace elements, such as selenium, zinc, arsenic, cadmium, and nickel, are found naturally in the environment, and human exposure derives from a variety of sources, including air, drinking water, and food. Trace elements are of particular interest given that the levels of exposure to them are potentially modifiable. In this review, we focus largely on the association between each of the trace elements noted above and risk of cancers of the lung, breast, colorectum, prostate, urinary bladder, and stomach. Overall, the evidence currently available appears to support an inverse association between selenium exposure and prostate cancer risk, and possibly also a reduction in risk with respect to lung cancer, although additional prospective studies are needed. There is also limited evidence for an inverse association between zinc and breast cancer, and again, prospective studies are needed to confirm this. Most studies have reported no association between selenium and risk of breast, colorectal, and stomach cancer, and between zinc and prostate cancer risk. There is compelling evidence in support of positive associations between arsenic and risk of both lung and bladder cancers, and between cadmium and lung cancer risk.
MSU Digital Commons Citation
Navarro Silvera, Stephanie A. and Rohan, Thomas E., "Trace elements and cancer risk: a review of the epidemiologic evidence" (2007). Department of Public Health Scholarship and Creative Works. 88.
Silvera, Stephanie A. Navarro, and Thomas E. Rohan. "Trace elements and cancer risk: a review of the epidemiologic evidence." Cancer Causes & Control 18, no. 1 (2007): 7-27.
Cancer Biology Commons, Chemicals and Drugs Commons, Clinical Epidemiology Commons, Community Health and Preventive Medicine Commons, Environmental Public Health Commons, Epidemiology Commons, Health and Medical Physics Commons, Health Services Administration Commons, Health Services Research Commons, International Public Health Commons, Other Public Health Commons, Patient Safety Commons, Public Health Education and Promotion Commons