Title

Comparing CYP2S1 and CYP102A1: Factors that influence the chemistry of CYP2S1

Presentation Type

Event

Start Date

27-4-2019 8:45 AM

End Date

27-4-2019 9:24 AM

Abstract

Cytochromes P450s have been investigated as drug targets for anticancer prodrugs (to be activated by P450 only in cancer cells). Current investigation involves mutating a well-studied P450 BM-3 to mimic the chemistry of CYP2S1. We tested different structured substrates and saw the enzymatic activity is affected when an acidic residue in the oxygen binding pocket is mutated to a methionine.

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Apr 27th, 8:45 AM Apr 27th, 9:24 AM

Comparing CYP2S1 and CYP102A1: Factors that influence the chemistry of CYP2S1

Cytochromes P450s have been investigated as drug targets for anticancer prodrugs (to be activated by P450 only in cancer cells). Current investigation involves mutating a well-studied P450 BM-3 to mimic the chemistry of CYP2S1. We tested different structured substrates and saw the enzymatic activity is affected when an acidic residue in the oxygen binding pocket is mutated to a methionine.