Elucidation and Differentiation of Glycan Isomers via Reductive Amination in MS/MS
Presentation Type
Poster
Faculty Advisor
Jinshan Gao
Access Type
Event
Start Date
26-4-2024 9:45 AM
End Date
26-4-2024 10:44 AM
Description
Glycomics is a rapidly developing field of biochemical research that has potential to serve as biomarkers for diseases. In recent decades, focus has been shifted towards the characterization of glycans through the use of tandem mass spectrometry. Glycans are simply any sugar molecule and is one of the four major macromolecules key for bodily function. Being able to distinguish between the different isomers serves great importance in glycomics and possible diagnosis for Central Nervous System Diseases. Glycans can differ in numerous ways and their structure can vary due to their complex branching and structures. Using a novel reagent, N-glycans are able to be analyzed through the use of Mass Spectrometry. Preliminary data analysis of MS/MS spectra of the glycans reveals distinct differences between the disaccharides.
Elucidation and Differentiation of Glycan Isomers via Reductive Amination in MS/MS
Glycomics is a rapidly developing field of biochemical research that has potential to serve as biomarkers for diseases. In recent decades, focus has been shifted towards the characterization of glycans through the use of tandem mass spectrometry. Glycans are simply any sugar molecule and is one of the four major macromolecules key for bodily function. Being able to distinguish between the different isomers serves great importance in glycomics and possible diagnosis for Central Nervous System Diseases. Glycans can differ in numerous ways and their structure can vary due to their complex branching and structures. Using a novel reagent, N-glycans are able to be analyzed through the use of Mass Spectrometry. Preliminary data analysis of MS/MS spectra of the glycans reveals distinct differences between the disaccharides.