Comparison of Caregiver-reported Dietary Intake Methods in Zellweger Spectrum Disorder
Presentation Type
Poster
Faculty Advisor
Mousumi Bose
Access Type
Event
Start Date
26-4-2024 12:45 PM
End Date
26-4-2024 1:44 PM
Description
Introduction: Zellweger spectrum disorder (ZSD), a rare genetic disease characterized by defects in peroxisome biogenesis, results in dysfunction of all organ systems, including feeding difficulties and reduced growth. Previous research has indicated potential benefits from dietary interventions in managing symptoms of other peroxisomal disorders, though studies focusing on dietary intake in ZSD are lacking. The purpose of this study was to determine nutrient intake in individuals with ZSD using two methods of dietary assessment as provided by family caregivers. Methods: Family caregivers participated in multiple 24-hour dietary recall interviews and completed 3-day food records for their child with a peroxisomal disorder over a 6-month period. Results: Family caregivers of 21 subjects (ages 0 to 33 years) with ZSD or related peroxisomal disorder completed 24-hour dietary recalls and 3-day food records on behalf of their child. Most subjects met or exceeded the Dietary Reference Intake (DRI) with the exception of fiber. Additionally, most subjects exceeded their recommended sugar intake. Energy and nutrient intake as recorded by dietary recall versus 3-day food record were highly correlated. Conclusion: This data shows that dietary assessment in ZSD is feasible using caregiver input. These findings may be applicable in dietary assessments for individuals with ZSD and similar disorders and a methodological consideration in clinical interventions.
Comparison of Caregiver-reported Dietary Intake Methods in Zellweger Spectrum Disorder
Introduction: Zellweger spectrum disorder (ZSD), a rare genetic disease characterized by defects in peroxisome biogenesis, results in dysfunction of all organ systems, including feeding difficulties and reduced growth. Previous research has indicated potential benefits from dietary interventions in managing symptoms of other peroxisomal disorders, though studies focusing on dietary intake in ZSD are lacking. The purpose of this study was to determine nutrient intake in individuals with ZSD using two methods of dietary assessment as provided by family caregivers. Methods: Family caregivers participated in multiple 24-hour dietary recall interviews and completed 3-day food records for their child with a peroxisomal disorder over a 6-month period. Results: Family caregivers of 21 subjects (ages 0 to 33 years) with ZSD or related peroxisomal disorder completed 24-hour dietary recalls and 3-day food records on behalf of their child. Most subjects met or exceeded the Dietary Reference Intake (DRI) with the exception of fiber. Additionally, most subjects exceeded their recommended sugar intake. Energy and nutrient intake as recorded by dietary recall versus 3-day food record were highly correlated. Conclusion: This data shows that dietary assessment in ZSD is feasible using caregiver input. These findings may be applicable in dietary assessments for individuals with ZSD and similar disorders and a methodological consideration in clinical interventions.
Comments
Additional Authors: Chelsea I. Donlon, Alyssa Smolen