Heterocyclic activated cycloaddition
Presentation Type
Abstract
Faculty Advisor
Magnus Bebbington
Access Type
Event
Start Date
25-4-2025 10:30 AM
End Date
25-4-2025 11:30 AM
Description
Oxadiazoles are an important class of molecules that play a role in pharmaceutical chemistry, materials science, and organic synthesis. We have developed a synthetic route to an oxadiazole that is suitable for further elaboration by a powerful class of ring-forming reactions, rapidly increasing molecular complexity. The structure was confirmed using Nuclear Magnetic Resonance spectroscopy. This study highlights the reactivity of oxadiazole-activated ring-forming reactions. This work indicates the potential for late-stage modification of oxadiazole-containing drug molecules, which allows for straightforward preparation of new drug candidates, perhaps with improved properties, which are not covered by chemical patents. Further studies will focus on expanding substrate scope of the reaction ring-forming reaction as well as optimizing product yields.
Heterocyclic activated cycloaddition
Oxadiazoles are an important class of molecules that play a role in pharmaceutical chemistry, materials science, and organic synthesis. We have developed a synthetic route to an oxadiazole that is suitable for further elaboration by a powerful class of ring-forming reactions, rapidly increasing molecular complexity. The structure was confirmed using Nuclear Magnetic Resonance spectroscopy. This study highlights the reactivity of oxadiazole-activated ring-forming reactions. This work indicates the potential for late-stage modification of oxadiazole-containing drug molecules, which allows for straightforward preparation of new drug candidates, perhaps with improved properties, which are not covered by chemical patents. Further studies will focus on expanding substrate scope of the reaction ring-forming reaction as well as optimizing product yields.
Comments
Poster presentation at the 2025 Student Research Symposium.