A cohort study of reproductive and hormonal factors and renal cell cancer risk in women

Document Type

Article

Publication Date

Winter 2-20-2007

Journal / Book Title

British Journal of Cancer volume

Abstract

We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had X5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR 1⁄4 2.41, 95% CI 1⁄4 1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk.

Comments

From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

DOI

10.1038/sj.bjc.6603629

Published Citation

Kabat, G. C., SA Navarro Silvera, A. B. Miller, and Thomas E. Rohan. "A cohort study of reproductive and hormonal factors and renal cell cancer risk in women." British journal of cancer 96, no. 5 (2007): 845-849.

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