Document Type
Article
Publication Date
Winter 2-20-2007
Journal / Book Title
British Journal of Cancer volume
Abstract
We examined the association of reproductive and hormonal factors with renal cell cancer risk in a cohort study of 89 835 Canadian women. Compared with nulliparous women, parous women were at increased risk (hazard ratio (HR) 1.78, 95% confidence interval (CI) 1.02–3.09), and there was a significant gradient of risk with increasing levels of parity: relative to nulliparous women, women who had X5 pregnancies lasting 4 months or more had a 2.4-fold risk (HR 1⁄4 2.41, 95% CI 1⁄4 1.27–4.59, P for trend 0.01). Ever use of oral contraceptives was associated with a modest reduction in risk. No associations were observed for age at first live birth or use of hormone replacement therapy. The present study provides evidence that high parity may be associated with increased risk of renal cell cancer, and that oral contraceptive use may be associated with reduced risk.
DOI
doi:10.1038/sj.bjc.6603629
MSU Digital Commons Citation
Kabat, GC; Navarro Silvera, Stephanie A.; Miller, AB; and Rohan, TE, "A cohort study of reproductive and hormonal factors and renal cell cancer risk in women" (2007). Department of Public Health Scholarship and Creative Works. 58.
https://digitalcommons.montclair.edu/public-health-facpubs/58
Published Citation
Kabat, G. C., SA Navarro Silvera, A. B. Miller, and Thomas E. Rohan. "A cohort study of reproductive and hormonal factors and renal cell cancer risk in women." British journal of cancer 96, no. 5 (2007): 845-849.
Included in
Clinical Epidemiology Commons, Community Health and Preventive Medicine Commons, Environmental Public Health Commons, Epidemiology Commons, Health Services Administration Commons, Health Services Research Commons, Hormones, Hormone Substitutes, and Hormone Antagonists Commons, International Public Health Commons, Maternal and Child Health Commons, Patient Safety Commons, Public Health Education and Promotion Commons, Reproductive and Urinary Physiology Commons, Women's Health Commons