Start Date
10-10-2023 3:45 PM
End Date
10-10-2023 5:00 PM
Access Type
Open Access
Abstract
Electrospray ionization (ESI) is an indispensable mass spectrometry method for solution phase analytes including environmental contaminants. While MS detectors measure no more than picoamps of ion current, conventional ESI methods produce a minimum of nanoamps (nA) current, wasting a large portion of analytes, and causing non-uniform responses in the analysis.
Recent research has developed methods to generate ESI in femtoamp (fA) currents and femto flow (fL/min) flow rates. When generating nanoscale initial charged droplets, the femto ionization regimes provide improved performances for hydrophilic analytes including glycans, glycopeptide, and intact proteins. This seminar also showcases how the low ion current regime may be utilized to ionize environmental contaminants in nonpolar extraction solvent. Lastly, femto ESI was utilized to generate individual ions for charge detection mass spectrometry, and for preparing single atom catalyst.
Biography
Dr. Anyin Li, B.S. in Chemistry from the Beijing Normal University; Ph.D. in Analytical Chemistry from Purdue University under the supervision of Dr. Graham Cooks; and Post doctorate training with Dr. Facundo Fernandez in the Georgia Institute of Technology. Since 2017, Dr. Li has joined the University of New Hampshire (UNH) as an assistant professor in the Department of Chemistry. In his research career, Dr. Li has produced >20 peer-reviewed publications and 3 patents.
Additional Links
ORCID
Analyzing Low-abundance Environmental Analytes using Mass Spectrometry
Electrospray ionization (ESI) is an indispensable mass spectrometry method for solution phase analytes including environmental contaminants. While MS detectors measure no more than picoamps of ion current, conventional ESI methods produce a minimum of nanoamps (nA) current, wasting a large portion of analytes, and causing non-uniform responses in the analysis.
Recent research has developed methods to generate ESI in femtoamp (fA) currents and femto flow (fL/min) flow rates. When generating nanoscale initial charged droplets, the femto ionization regimes provide improved performances for hydrophilic analytes including glycans, glycopeptide, and intact proteins. This seminar also showcases how the low ion current regime may be utilized to ionize environmental contaminants in nonpolar extraction solvent. Lastly, femto ESI was utilized to generate individual ions for charge detection mass spectrometry, and for preparing single atom catalyst.